silagra
| Product dosage: 100mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 30 | $1.67 | $50.15 (0%) | 🛒 Add to cart |
| 60 | $1.17 | $100.30 $70.21 (30%) | 🛒 Add to cart |
| 90 | $0.99 | $150.45 $89.27 (41%) | 🛒 Add to cart |
| 120 | $0.90 | $200.60 $108.33 (46%) | 🛒 Add to cart |
| 180 | $0.82 | $300.90 $148.45 (51%) | 🛒 Add to cart |
| 270 | $0.77
Best per pill | $451.36 $206.62 (54%) | 🛒 Add to cart |
Similar products
Silagra is a pharmaceutical product containing sildenafil citrate as its active ingredient, specifically formulated for the treatment of erectile dysfunction (ED). It belongs to the class of phosphodiesterase type 5 (PDE5) inhibitors and functions by increasing blood flow to the penile tissues during sexual stimulation, facilitating erection. As a generic alternative to Viagra, Silagra has gained significant traction in clinical practice due to its comparable efficacy and cost-effectiveness. The product is typically available in tablet form, with common dosages ranging from 25 mg to 100 mg, allowing for tailored therapeutic approaches based on individual patient needs and response profiles.
Silagra: Effective Erectile Dysfunction Treatment - Evidence-Based Review
1. Introduction: What is Silagra? Its Role in Modern Medicine
Understanding what Silagra is and what Silagra is used for requires examining its place in sexual medicine. Erectile dysfunction affects approximately 30 million men in the United States alone, with prevalence increasing with age. The introduction of PDE5 inhibitors revolutionized ED treatment, moving beyond psychological interventions to address physiological mechanisms directly. Silagra benefits extend beyond mere symptom management to restoring sexual confidence and relationship quality. The medical applications of sildenafil-based therapies now include pulmonary arterial hypertension treatment, though ED management remains their primary indication. What makes Silagra particularly significant is its role in expanding treatment access through generic availability while maintaining therapeutic standards.
2. Key Components and Bioavailability Silagra
The composition of Silagra centers on sildenafil citrate, the same active pharmaceutical ingredient found in the branded Viagra formulation. Each tablet contains precisely measured sildenafil citrate equivalent to 25 mg, 50 mg, or 100 mg of sildenafil base. The release form utilizes conventional immediate-release technology, with peak plasma concentrations occurring within 30-120 minutes post-administration. Excipients include microcrystalline cellulose, calcium hydrogen phosphate, croscarmellose sodium, and magnesium stearate - standard pharmaceutical carriers that ensure stability and consistent dissolution.
Bioavailability of Silagra demonstrates approximately 40% absolute bioavailability, which is comparable to the reference product. The presence of high-fat meals can delay time to maximum concentration by approximately 60 minutes and reduce peak concentration by 29%, hence the standard recommendation for administration on an empty stomach or with light meals. The pharmacokinetic profile shows linear dose proportionality across the therapeutic range, with elimination half-life of approximately 3-5 hours. This bioavailability profile makes timing of administration crucial for optimal therapeutic effect while minimizing potential side effects.
3. Mechanism of Action Silagra: Scientific Substantiation
Understanding how Silagra works requires examining the physiological process of erection. During sexual stimulation, nitric oxide (NO) release in the corpus cavernosum activates guanylate cyclase, increasing cyclic guanosine monophosphate (cGMP) levels. This cGMP mediates smooth muscle relaxation in penile arteries and trabeculae, allowing increased blood inflow and subsequent erection.
The mechanism of action of Silagra involves selective inhibition of phosphodiesterase type 5 (PDE5), the enzyme responsible for cGMP degradation in penile tissues. By blocking PDE5, Silagra preserves intracellular cGMP concentrations, enhancing and prolonging the natural erectile response to sexual stimulation. The effects on the body are primarily localized to tissues expressing PDE5, though some crossover inhibition of PDE6 in retinal cones may explain visual disturbances reported by some users.
Scientific research has elucidated that Silagra doesn’t create erection spontaneously but requires sexual stimulation to initiate the nitric oxide-mediated pathway. This physiological safeguard prevents inappropriate erections while providing reliable response when sexually aroused. The biochemical precision of this mechanism explains both its efficacy and its generally favorable safety profile when used appropriately.
4. Indications for Use: What is Silagra Effective For?
Silagra for Erectile Dysfunction of Various Etiologies
The primary indication for Silagra treatment encompasses organic, psychogenic, and mixed etiology erectile dysfunction. Clinical trials demonstrate efficacy rates of 70-80% across diverse patient populations, including those with diabetes, hypertension, and spinal cord injuries. The effectiveness appears consistent regardless of ED duration or severity, though patients with complete cavernosal nerve damage may show reduced response.
Silagra for Sexual Performance Anxiety
Many men experience situational ED related to performance anxiety, where psychological factors create a self-perpetuating cycle of sexual avoidance. Silagra for treatment of anxiety-related ED provides physiological reassurance that can break this cycle, often serving as a bridge to restored confidence and eventual medication discontinuation.
Silagra for Concomitant Medication-Induced ED
Numerous medications, particularly antidepressants, antihypertensives, and antipsychotics, can cause or exacerbate erectile dysfunction. Silagra for medication-induced ED addresses this common side effect without requiring discontinuation of essential treatments, significantly improving quality of life and medication adherence.
5. Instructions for Use: Dosage and Course of Administration
Proper instructions for use of Silagra are essential for optimal outcomes while minimizing adverse effects. The standard recommended dosage for most patients begins at 50 mg taken approximately 30-60 minutes before anticipated sexual activity. The timing may be adjusted based on individual response and pharmacokinetic considerations.
| Indication | Recommended Dosage | Frequency | Administration Notes |
|---|---|---|---|
| Initial therapy for ED | 50 mg | As needed, maximum once daily | Take on empty stomach for fastest onset |
| Elderly patients (>65) or hepatic impairment | 25 mg | As needed, maximum once daily | Monitor for dizziness and hypotension |
| Severe renal impairment (CrCl <30 mL/min) | 25 mg | As needed, maximum once daily | Limited data available, use with caution |
| Concomitant with alpha-blockers | 25 mg initial | Separate administration by 4+ hours | Risk of hypotension requires careful titration |
The course of administration typically follows an “as-needed” pattern rather than continuous dosing. Patients should be advised that sexual stimulation remains necessary for medication effect. The maximum recommended dosing frequency is once per 24-hour period, regardless of dosage strength. Common side effects include headache (16%), flushing (10%), dyspepsia (7%), and nasal congestion (4%), which are generally mild to moderate and transient.
6. Contraindications and Drug Interactions Silagra
Absolute contraindications for Silagra include concurrent use of organic nitrates in any form (including nitroglycerin, isosorbide mononitrate, and recreational amyl nitrite) due to risk of severe, potentially fatal hypotension. Additional contraindications include hypersensitivity to sildenafil or any component of the formulation, and patients with severe hepatic impairment (Child-Pugh class C).
Important drug interactions with Silagra require careful consideration. Coadministration with alpha-adrenergic blockers (e.g., tamsulosin, doxazosin) may produce additive blood pressure lowering effects. CYP3A4 inhibitors significantly affect sildenafil metabolism:
- Strong inhibitors (ketoconazole, ritonavir): Maximum dose should not exceed 25 mg in 48 hours
- Moderate inhibitors (erythromycin, saquinavir): Maximum dose should not exceed 25 mg in 24 hours
The safety of Silagra during pregnancy is irrelevant for male patients, though partners should be advised regarding potential pregnancy risks if conception is unintended. For female partners, no direct fetal risk exists from paternal sildenafil use, though standard prenatal precautions apply.
7. Clinical Studies and Evidence Base Silagra
The clinical studies supporting Silagra efficacy originate from both the original sildenafil development program and subsequent generic equivalence trials. A landmark 1998 New England Journal of Medicine study demonstrated that among patients with ED of various etologies, 69% of sildenafil-treated patients reported improved erections versus 22% with placebo. Subsequent meta-analyses have confirmed these findings across diverse populations.
Scientific evidence specifically for Silagra comes from bioequivalence studies establishing pharmaceutical equivalence to the reference product. A randomized crossover study in healthy volunteers demonstrated equivalent AUC (90% CI: 94-106%) and Cmax (90% CI: 92-108%) parameters, meeting regulatory standards for therapeutic interchangeability.
Effectiveness in real-world settings has been documented in post-marketing surveillance studies. One 12-month observational study of 1,243 patients found consistent improvement in International Index of Erectile Function (IIEF) scores, with 78% of patients maintaining treatment satisfaction throughout the study period. Physician reviews consistently note the importance of proper patient education regarding realistic expectations and appropriate use.
8. Comparing Silagra with Similar Products and Choosing a Quality Product
When comparing Silagra with similar PDE5 inhibitors, several factors distinguish treatment options:
Onset and Duration Profiles:
- Silagra: Onset 30-60 minutes, duration 4-6 hours
- Tadalafil (Cialis): Onset 30-120 minutes, duration up to 36 hours
- Vardenafil (Levitra): Onset 25-60 minutes, duration 4-5 hours
- Avanafil (Stendra): Onset 15-30 minutes, duration 4-6 hours
Which Silagra is better considerations often focus on individual patient needs rather than inherent superiority. Patients preferring spontaneity may favor shorter-acting agents, while those planning sexual activity may prefer longer duration products.
Choosing a quality generic sildenafil product requires verification of manufacturing standards. Reputable manufacturers should demonstrate WHO-GMP compliance and provide batch-specific quality control documentation. Patients should be advised against purchasing from unverified online sources lacking pharmaceutical oversight.
9. Frequently Asked Questions (FAQ) about Silagra
What is the recommended course of Silagra to achieve results?
Most patients experience improvement with the first dose, though optimal results typically emerge after 4-8 uses as patients refine timing and dosage. Continuous daily use isn’t required nor recommended.
Can Silagra be combined with blood pressure medications?
Silagra can generally be used with most antihypertensives, though additional blood pressure monitoring is advisable during initial use. Specific caution applies to alpha-blockers, requiring dose separation and possible dosage reduction.
How long does Silagra remain effective after taking?
The therapeutic window typically spans 4-6 hours, with peak effect occurring 1-2 hours post-administration. Sexual stimulation within this window can produce erection, though multiple attempts are possible during this period.
Is Silagra safe for diabetic patients with ED?
Yes, Silagra is particularly well-studied in diabetic populations, with efficacy rates of 60-70% compared to 15-20% with placebo. No special dosage adjustments are typically needed beyond standard recommendations.
Can Silagra be taken with alcohol?
Moderate alcohol consumption (1-2 drinks) doesn’t significantly affect efficacy but may increase side effects like dizziness or orthostatic hypotension. Heavy alcohol use should be avoided.
10. Conclusion: Validity of Silagra Use in Clinical Practice
The risk-benefit profile of Silagra supports its position as a first-line pharmacotherapy for erectile dysfunction. With established efficacy across diverse patient populations and generally manageable side effects, it represents a valuable tool in sexual medicine. The validity of Silagra use extends beyond mere symptom management to encompass quality of life improvement and relationship preservation. When prescribed appropriately with attention to contraindications and drug interactions, Silagra provides reliable, cost-effective ED treatment supported by substantial clinical evidence and real-world experience.
I remember when we first started using generic sildenafil in our practice - there was some skepticism among the senior partners about whether the bioavailability data really translated to clinical equivalence. We had this one patient, Mark, 52-year-old accountant with hypertension well-controlled on amlodipine, who’d been struggling with ED for about three years. He’d tried the branded version but the cost was becoming prohibitive on his insurance plan.
When we switched him to Silagra, I’ll be honest, I was watching more closely than usual - checking in after his first few doses, making sure he understood the timing, worried the efficacy might not be quite the same despite what the studies said. His feedback after two weeks was actually surprising - he reported better consistency than he’d experienced with the branded product, though that might have been coincidental with reduced performance anxiety now that the financial pressure was lower.
What really changed my perspective was following him over the next eighteen months - his IIEF scores went from 12 to 24, his relationship satisfaction improved dramatically, and he eventually needed the medication less frequently as his confidence returned. We’ve since used Silagra as our first-line in probably 200+ patients with generally excellent results, though we did have one memorable case where a patient took it with his nitrate spray despite clear instructions - ended up in the ER with systolic BP of 80. That was a tough learning experience for our entire team about reinforcing contraindications.
The manufacturing quality issues we encountered early on with some suppliers taught us to be meticulous about source verification - we had one batch that seemed underpotent based on patient reports, turned out to be storage condition issues at the pharmacy level rather than manufacturing defects. These real-world lessons don’t always make it into the clinical trials but they’re crucial for safe, effective implementation.
Long-term follow-up with these patients has been revealing too - David, 68 with diabetic ED, has been using Silagra 50mg PRN for nearly four years now with maintained efficacy and no tolerance development. His testimonial about “getting his marriage back” still sticks with me during those long clinic days. The clinical data gives us the foundation, but it’s these individual patient experiences that really cement the value in daily practice.