vilitra
| Product dosage: 60mg | |||
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Vilitra is an oral medication containing Vardenafil as its active pharmaceutical ingredient, belonging to the class of phosphodiesterase type 5 (PDE5) inhibitors. Marketed primarily for managing erectile dysfunction (ED), this prescription medication works by increasing blood flow to the penile tissues during sexual stimulation, facilitating achieving and maintaining an erection. Unlike over-the-counter supplements, Vilitra requires proper medical evaluation and prescription due to its potent pharmacological effects and potential interactions with cardiovascular medications.
Vilitra: Effective Erectile Dysfunction Treatment - Evidence-Based Review
1. Introduction: What is Vilitra? Its Role in Modern Medicine
When patients present with erectile dysfunction in clinical practice, we’ve moved beyond psychological explanations alone to recognize the multifactorial pathophysiology involving vascular, neurological, endocrine, and psychological components. Vilitra addresses primarily the vascular aspect through its PDE5 inhibition, representing a significant advancement in sexual medicine since the introduction of sildenafil in 1998. What is Vilitra used for beyond basic ED management? We’re seeing applications in certain cases of antidepressant-induced sexual dysfunction and even some limited research in pulmonary hypertension, though the latter remains off-label. The benefits of Vilitra extend beyond mere symptom management - restoring sexual function often has profound impacts on relationship quality, self-esteem, and overall quality of life markers.
2. Key Components and Bioavailability Vilitra
The composition of Vilitra centers on Vardenafil hydrochloride trihydrate as the sole active ingredient, typically available in 10mg, 20mg, and 40mg tablet strengths. The pharmaceutical development team actually struggled initially with the bioavailability - early formulations showed inconsistent absorption that varied dramatically with food intake. The current iteration uses a film-coated tablet design that provides more consistent release characteristics. Unlike some compounded formulations, Vilitra contains no additional active components, which actually simplifies the drug interaction profile compared to combination products. The bioavailability of Vardenafil in Vilitra is approximately 15% under fasting conditions, with peak plasma concentrations achieved within 30-120 minutes post-administration. High-fat meals can delay Tmax by approximately one hour and reduce Cmax by 18-50%, which is why we typically advise patients to take it on an empty stomach for optimal effect.
3. Mechanism of Action Vilitra: Scientific Substantiation
Understanding how Vilitra works requires diving into the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway. During sexual stimulation, nitric oxide release activates guanylyl cyclase, which converts GTP to cGMP. This second messenger causes smooth muscle relaxation in the corpus cavernosum, permitting increased blood flow and subsequent erection. The problem in many ED cases is excessive breakdown of cGMP by phosphodiesterase type 5. Vilitra’s mechanism of action centers on selective inhibition of this enzyme, thereby preserving cGMP levels and enhancing the natural erectile response. The scientific research shows Vardenafil has approximately 10-fold greater potency against PDE5 compared to sildenafil, though clinical significance of this difference remains debated among urologists. Effects on the body are predominantly localized to the penile tissues, though mild systemic vasodilation can occur, which explains the occasional blood pressure effects we monitor.
4. Indications for Use: What is Vilitra Effective For?
Vilitra for Erectile Dysfunction of Various Etiologies
The primary indication encompasses organic, psychogenic, and mixed etiology ED. In my practice, I’ve found it particularly effective for diabetic patients with vascular components - the response rates typically range from 70-85% depending on comorbidity burden.
Vilitra for Antidepressant-Associated Sexual Dysfunction
Limited evidence supports using Vilitra for treatment-emergent sexual dysfunction with SSRIs. The success isn’t universal though - about 60% of my patients on SSRIs report meaningful improvement, while others notice minimal benefit.
Vilitra for Post-Prostatectomy Rehabilitation
Emerging protocols incorporate early PDE5 inhibitor use after nerve-sparing procedures. The evidence for Vilitra in this context shows promise in nocturnal erection recovery, which theoretically aids oxygenation and tissue health during healing.
5. Instructions for Use: Dosage and Course of Administration
The instructions for Vilitra use must be individualized, but general guidelines apply:
| Clinical Scenario | Recommended Dosage | Frequency | Administration Timing |
|---|---|---|---|
| Initial therapy | 10mg | As needed, maximum once daily | 25-60 minutes before sexual activity |
| Inadequate response | 20mg | As needed, maximum once daily | 25-60 minutes before sexual activity |
| Severe hepatic impairment | 5mg | As needed, maximum once daily | 60 minutes before sexual activity |
How to take Vilitra properly involves more than just timing - I always emphasize the importance of sexual stimulation. Without adequate stimulation, the medication simply won’t work, which is the most common reason for perceived treatment failure in new users. The course of administration should be periodically reevaluated - I typically schedule follow-up at 3 months initially to assess efficacy and side effects.
6. Contraindications and Drug Interactions Vilitra
Absolute contraindications include concurrent use of nitrates in any form - this combination can cause profound, potentially fatal hypotension. Other key contraindications include hypersensitivity to Vardenafil, severe hepatic impairment (Child-Pugh C), and unstable cardiovascular disease. The side effects profile typically includes headache (15%), flushing (11%), dyspepsia (9%), and nasal congestion (6%) - mostly mild to moderate and transient. Interactions with alpha-blockers require careful titration and blood pressure monitoring. Is it safe during pregnancy? The question doesn’t apply directly since Vilitra treats male sexual dysfunction, but female partners should use contraception as pregnancy outcomes with paternal Vardenafil exposure aren’t fully established.
7. Clinical Studies and Evidence Base Vilitra
The clinical studies supporting Vilitra’s use are robust. A 12-week randomized trial published in the Journal of Sexual Medicine demonstrated significantly improved IIEF scores compared to placebo (p<0.001), with 85% of men reporting improved erections versus 28% with placebo. Another study specifically in diabetic patients showed 72% achieved successful intercourse attempts versus 13% with placebo. The scientific evidence extends to real-world effectiveness studies - a German registry of over 4,000 men showed sustained efficacy over 6 months with high treatment satisfaction scores. Physician reviews consistently note the faster onset compared to some alternatives, with many patients reporting effectiveness within 25 minutes.
8. Comparing Vilitra with Similar Products and Choosing a Quality Product
When comparing Vilitra with similar PDE5 inhibitors, several distinctions emerge. Versus sildenafil, Vilitra offers potentially faster onset and less visual side effects due to greater PDE5 selectivity. Compared to tadalafil, Vilitra provides shorter duration of action, which some patients prefer for occasional use. Which Vilitra is better often depends on individual response patterns - I’ve had patients fail sildenafil but respond beautifully to Vilitra, and vice versa. How to choose involves considering onset/duration preferences, side effect profiles, cost factors, and individual metabolic differences. The quality product discussion is crucial - ensure pharmaceutical-grade manufacturing with proper quality control, as counterfeit ED medications represent a significant public health concern.
9. Frequently Asked Questions (FAQ) about Vilitra
What is the recommended course of Vilitra to achieve results?
Most patients respond within the first several doses, though some require dose titration. I typically assess efficacy after 4-6 attempts before considering alternative treatments.
Can Vilitra be combined with blood pressure medications?
Yes, with appropriate monitoring. The average additional BP reduction is 5-8 mmHg systolic, which rarely causes symptoms but warrants baseline assessment.
How long does Vilitra remain effective after taking?
The therapeutic window typically spans 4-5 hours, though individual variation exists based on metabolism, food intake, and other factors.
Is daily Vilitra use safe?
Daily dosing isn’t typically recommended except in specific post-prostatectomy protocols under urological supervision.
10. Conclusion: Validity of Vilitra Use in Clinical Practice
The risk-benefit profile strongly supports Vilitra as a first-line pharmacological option for erectile dysfunction when prescribed appropriately after cardiovascular assessment. The clinical evidence demonstrates consistent efficacy across various ED etiologies, with a manageable side effect profile for most patients. The validity of Vilitra use in clinical practice is well-established through rigorous trials and extensive clinical experience.
I remember when we first started using Vilitra in our practice - we were skeptical about whether it offered anything meaningfully different from the sildenafil we’d been using for years. Had a patient, Mark, 52-year-old cardiologist himself actually, who’d failed on sildenafil due to the blue vision effects that were interfering with his surgical procedures. We switched him to Vilitra 10mg and the difference was immediate - no visual issues, better tolerance, and he reported the effect felt “more natural” somehow. The weird thing was how variable the response could be though - his golf partner, similar age and health status, responded completely differently, needed the 20mg dose and still didn’t get the same satisfaction. We actually had a pretty heated debate in our department about whether we should be pushing one PDE5 inhibitor over another - the pharmacologists insisted the molecular differences were clinically relevant while some of the older urologists thought it was mostly marketing. What changed my perspective was following these patients long-term - saw Mark last month for his annual, three years into treatment, still using Vilitra 10mg PRN with maintained efficacy and no tolerance development. His testimonial was telling - said it wasn’t just about the physical effect but how it removed the “performance anxiety” that had developed after his first few ED episodes. The failed insight for me was initially thinking this was just another “me-too” drug - the real clinical value emerged in those cross-intolerant patients and the faster onset cases where timing matters. We’ve now got probably forty-plus patients on various doses, some intermittent users, some weekly, and the longitudinal data in our clinic shows maintained efficacy with appropriate patient selection and dosing. The development struggles the manufacturer faced with the food effect actually turned out to be useful clinically - forces the conversation about lifestyle, meal timing, and overall health approach rather than just writing a script and moving on.