Prescription medicine information: Prednisolone should only be used under the direction of a qualified healthcare professional.
✓ Evidence-aware medication guide

Understand prednisolone before you take it.

A clear, patient-friendly overview of uses, precautions, side effects and questions to discuss with your doctor or pharmacist.

Medication overview

What is prednisolone?

Prednisolone is a corticosteroid used to reduce inflammation and modify immune responses. Clinicians may prescribe it for a range of conditions, including some allergies, inflammatory disorders, autoimmune diseases and other health problems.

Important: The right dose and duration depend on your diagnosis, other medicines and individual health risks. Do not start, change or stop treatment based on website information alone.
TypeCorticosteroid
ActionReduces inflammation
AccessPrescription required

Why it may be prescribed

Prednisolone can be used when inflammation or an overactive immune response is contributing to symptoms. The exact reason for prescribing it should be explained by your clinician.

  • Inflammatory and autoimmune conditions
  • Severe allergic reactions or asthma flare-ups
  • Some skin, blood or joint disorders
  • Other specialist-directed uses

Before taking prednisolone

Tell your clinician about infections, diabetes, high blood pressure, eye problems, stomach ulcers, osteoporosis, pregnancy or plans for vaccination. Also provide a complete list of medicines and supplements.

Infection warning: Corticosteroids can reduce immune responses. Seek professional advice promptly if you develop signs of infection or have been exposed to chickenpox, shingles or measles.

Possible side effects

Effects vary by dose and duration. Short courses may cause sleep changes, mood changes, indigestion or increased appetite. Longer or higher-dose treatment can carry additional risks that require monitoring.

Do not stop suddenly without advice

After certain doses or treatment durations, prednisolone may need to be reduced gradually. Your prescriber will tell you whether a taper is required.

Frequently asked

Questions to take to your clinician.

Can I take prednisolone with food?

It is often taken with food to reduce stomach irritation, but follow the directions on your prescription label.

What should I do if I miss a dose?

Instructions can depend on your schedule. Check the patient leaflet or contact a pharmacist rather than doubling a dose.

Can prednisolone affect sleep or mood?

Some people notice insomnia, restlessness or mood changes. Tell your clinician about severe, sudden or worrying changes.

Can I have vaccines?

Some vaccines may not be appropriate during immune-suppressing treatment. Ask your clinician before vaccination.

Worried about a reaction or dose?

Contact a qualified doctor, pharmacist, urgent care service or local emergency number based on the severity of symptoms.

Seek local medical help